Securing a job after completing a B.Tech degree from open universities can depend on a lot of things. If it is only based on the degree it could be difficult. 

If you want to go for MNCs you have to start by joining smaller organizations and start-ups. Here you can have the chance of getting hired based on your knowledge and skills. Try to improve your writing skills, communication skills, aptitude skills, etc.

Practice mock interviews, get familiar with all the current trends and topics. Prepare for questions like “Where do you see yourself in 5 years?” etc.

Improve your domain knowledge, practical knowledge, keep yourself updated and familiar with the recent trends in interviews. Learn from your peers and how they approach the interviews. More practice will increase your chances of getting a job.