The program focuses on developments in the biological and computational sciences relating to genome sequences, and the program is designed to take advantage of collaboration between the University of Tennessee, Knoxville, and the Oak Ridge National Laboratory. Students are trained in emerging areas of genome science, with emphasis on genomics, structural biology, proteomics, computational biology and bioinformatics, and bioanalytical technologies. Scientists from both campuses participate in teaching. Research projects pursued for either the MS or PhD are mentored by a faculty member from either campus. A year-long introductory course in Genome Science and Technology focuses on inquiry conducted on a genome-wide scale. Laboratory rotations during the first year offer students hands-on experience in a variety of focus areas.

Applicants are expected to have a background in the biological, physical, or computational sciences. Requirements for admission are one year of general biology or the equivalent; two years of chemistry, including one year of general chemistry and one year of introductory organic chemistry with laboratory; one year of calculus; one year of physics; at least 8 credit hours in cognate sciences related to the program; a GRE score; three letters of recommendation; and a minimum grade point average of 3.0 out of 4.0. Course work in genetics, cell biology, and computer sciences is advantageous. Superior students, deficient in one or more of the above requirements, may be admitted at the discretion of the program admissions committee. Deficiencies will be made up as a part of the courses taken by the individual student.