Indiana University School of Dentistry is one of the oldest dental schools in the nation. It was established as the Indiana Dental College in 1879 and became part of Indiana University in 1925. In 1933, IU built a facility to house the school at its current site on what is now known as the Indiana University-Purdue University Indianapolis campus.

Today this sprawling, five-story edifice is composed of the original building and two major additions. It is the only dental school in the Hoosier state.