The subject of chemistry is typically broken into more focused disciplines, including organic chemistry, inorganic chemistry, physical chemistry, analytical chemistry, theoretical chemistry, computational chemistry, biochemistry, and materials chemistry. A degree in chemistry examines these topics to promote a fundamental understanding of the world and the application of this knowledge in solving technological problems. Professional chemists apply their knowledge in many different areas ranging from environmental processes to the development of new materials and renewable energy. They work in academic environments, high-tech start-ups, and research and development laboratories associated with practically every advanced technological field including medicine, computing, energy, agriculture, and biotechnology.

The chemistry degree at the Colorado School of Mines consists of a total of 133.5 credit hours and is founded in rigorous fundamental science, complemented by application of these principles to minerals, energy, materials, or environmental fields. For example, specific B.S. curricular tracks emphasizing environmental chemistry or biochemistry are offered along with a more flexible track which can be tailored to optimize preparation consistent with students' career goals. Those aspiring to enter Ph.D. programs in chemistry are encouraged to include undergraduate research beyond the minimum required among their elective hours. Others interested in industrial chemistry may choose area of special interest courses in chemical engineering or metallurgy, for example. A significant number of students complete degrees in both chemistry and chemical engineering as an excellent preparation for industrial careers. Sustainability and the principles of green chemistry are valued throughout the curriculum and are the focus of many of the research areas.