- Cytotechnologists (not to be confused with cytogeneticists) prepare cellular samples (such as those from PAP smears and biopsies) for study under the microscope and assist in the diagnosis of disease by the examination of these samples. Histotechnologists prepare body tissue for examination by a pathologist to diagnose body dysfunction and malignancy and identify tissue structures, cell component and staining characteristics, relate these to physiologic functions, implement and evaluate new techniques and procedures, make quality control judgments and apply principles of management and education methodology when appropriate.