A recent invention in Bradford has identified a new carrier molecule that reduces the polarity of polar drugs. The modification makes significant (0.5-1 log fold) improvements to the logP of highly-polar hydroxyl compounds and is predicted to confer favourable uptake and distribution properties on any linked drug compound.
Summary of project
The programme of work will provide a rounded Medicinal Chemistry education. Work will be phased so that simpler compounds are prepared and tested in the first year and a comprehensive range of chemical and biological techniques learnt. More complex targets will be attempted as the studentÕs experience and confidence grow.
