New Delhi: A new antibacterial small molecule (IITR00693) was discovered by researchers at the Indian Institute of Technology (IIT) Roorkee that may aid in the struggle against infections that are resistant to the treatment. Prof. Ranjana Pathania, Department of Biosciences and Bioengineering, IIT Roorkee, was in charge of the study.
As per IIT Roorkee, the molecule was discovered after a thorough screening process that has demonstrated strong antibacterial activity against a variety of gram-positive and gram-negative bacteria, including some of the most problematic drug-resistant types.
The discovery of this novel chemical offers the possibility for more robust and specialized therapeutics since many bacterial illnesses become resistant to the current therapies. IITR00693 functions as a double-edged blade that not only eliminates even the most tenacious bacteria but also stops the evolution of resistance, guaranteeing its continued efficacy for future generations.
The rise of antibiotic resistance among skin-infecting bacteria poses an urgent threat to public health and has driven search for novel medicines. An alternative for treating infections brought on by microorganisms with drug resistance is to increase the potency of presently prescribed medicines. Staphylococcus aureus and Pseudomonas aeruginosa, two well-known multidrug-resistant skin-infecting bacteria, are targeted by IITR00693, which fight against dangerous superbugs. The mixture de-energizes the bacterial cells and destroys their membrane through a new dual method of action. The combination exhibits a very low propensity for the emergence of resistance, which is a significant issue for many antibiotics.
"We are currently aiming to further enhance the molecule into a viable medicinal drug that can be tested in clinical trials," IIT Roorkee Director Prof. KK Pant stated. This is a crucial stage in the creation of novel antibiotics because it will enable the assessment of the molecule's effectiveness, safety, and potential adverse effects.
Prof Ranjana Pathania, Department of Biosciences and Bioengineering, IIT Roorkee, said, “We aimed to find a tiny chemical that may potentiate currently used antibiotics. A brand-new antibacterial small molecule called IITR00693 enhances polymyxin B's ability to fight off Staphylococcus aureus and Pseudomonas aeruginosa. Here, we looked closely at how this connection works as well as the molecule's potential to fight Paeruginosa and Saureus-caused soft tissue infections.
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